The overall research project will focus on brain and gut endothelial cell dysfunction in ischemic stroke. These studies will contribute to our lab’s overall goal of understanding the anti-inflammatory mechanisms of tissue nonspecific alkaline phosphatase (TNAP) in the central and enteric nervous system. Two specific projects are available to study the role of alkaline phosphatases in ischemic stroke: 1) tissue nonspecific alkaline phosphatase (TNAP)-mediated regulation of blood-brain barrier function and 2) alkaline phosphatases as modifiers of the gut-brain-microbiota axis. Please contact Dr. Candice Brown (firstname.lastname@example.org) for more information.
Congratulations goes to MD/PhD student, Divine Nwafor! Divine secured a first place poster award at the APSA Northeast Regional Conference! His poster was entitled, ” Tissue-Nonspecific Alkaline Phosphatase Plays a Pivotal Role in Maintaining Brain Microvascular Endothelial Cell (BMEC) in a Model of Acute Systemic Inflammation.
The conference was held from January 9-11, 2021.
Congratulations to Allison Brichacek, who was recently selected to attend the St. Jude National Graduate Student Symposium to be held virtually from April 6-8, 2021. Invitation to the NGSS is very competitive and invitations are extended to a select group of Ph.D. students who have been nominated by a faculty member from their university and selected by a faculty review committee at St. Jude. Great job, Allison!
Shoreline Biome recently featured our laboratory’s work in an on-demand webinar. We used Shoreline Biome’s StrainID kit combined with PacBio sequencing for long-read 16S rRNA sequencing. Our results were used by Shoreline Biome to develop an analysis pipeline featuring their proprietary SB Analyzer software, DADA2, and QIIME2. This simplifies the bioinformatics workflow for many research teams.
Congratulations to Divine Nwafor, Allison Brichacek, and former master’s student, Maggie Dransfeld, on their recent publication:
Disruption of metabolic, sleep, and sensorimotor functional outcomes in a female transgenic mouse model of Alzheimer’s disease. Behav Brain Res. 2020 Nov 1;398:112983.
See our recent editorial feature on stroke microbiome research.
Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke
Nada El Husseini, Cheryl Bushnell, Candice M. Brown, Deborah Attix, Natalia S. Rost, Gregory P. Samsa, Carol A. Colton, Larry B. Goldstein
Allison presented her poster at the Miami Winter Symposium 2020: Molecular Mechanisms Linking the Microbiome and Human Health held Jan 26-29 in Miami, FL. This research was performed in collaboration with Shoreline Biome.
Divine recently received a travel award to the annual American Physician-Scientist Association (APSA) meeting held in Chicago, IL on April 3-5, 2020. This meeting attracts physician-scientists and aspiring physician-scientists from across the nation. Great job!
Allison Brichacek, Sophia Kenney, and Maria Mace presented posters represented at the 1st Annual Rust Belt Microbiome Conference. The conference was held at Carnegie Mellon University in Pittsburgh, PA from November 4-5. See Publications page for details. Congratulations, ladies!