Postdoctoral position available to study the role of alkaline phosphatases in ischemic stroke

Please see recent posting in SfN Neurojobs and our Research page on TNAP and the blood-brain barrier.

The overall research project will focus on brain and gut endothelial cell dysfunction in ischemic stroke. These studies will contribute to our lab’s overall goal of understanding the anti-inflammatory mechanisms of tissue nonspecific alkaline phosphatase (TNAP) in the central and enteric nervous system. Two specific projects are available to study the role of alkaline phosphatases in ischemic stroke: 1) tissue nonspecific alkaline phosphatase (TNAP)-mediated regulation of blood-brain barrier function and 2) alkaline phosphatases as modifiers of the gut-brain-microbiota axis. Please contact Dr. Candice Brown ( for more information.

Divine Nwafor wins 1st place poster award at 2021 American Physician Scientist Association (APSA) Regional Conference

Congratulations goes to MD/PhD student, Divine Nwafor! Divine secured a first place poster award at the APSA Northeast Regional Conference! His poster was entitled, ” Tissue-Nonspecific Alkaline Phosphatase Plays a Pivotal Role in Maintaining Brain Microvascular Endothelial Cell (BMEC) in a Model of Acute Systemic Inflammation.

The conference was held from January 9-11, 2021.

Allison Brichacek selected for 2021 St. Jude National Graduate Student Symposium (NGSS)

Congratulations to Allison Brichacek, who was recently selected to attend the St. Jude National Graduate Student Symposium to be held virtually from April 6-8, 2021. Invitation to the NGSS is very competitive and invitations are extended to a select group of Ph.D. students who have been nominated by a faculty member from their university and selected by a faculty review committee at St. Jude. Great job, Allison!

On-demand Shoreline Biome webinar features lab’s gut microbiome research

Shoreline Biome recently featured our laboratory’s work in an on-demand webinar. We used Shoreline Biome’s StrainID kit combined with PacBio sequencing for long-read 16S rRNA sequencing. Our results were used by Shoreline Biome to develop an analysis pipeline featuring their proprietary SB Analyzer software, DADA2, and QIIME2. This simplifies the bioinformatics workflow for many research teams.

New AD publication in Behavioural Brain Research

Congratulations to Divine Nwafor, Allison Brichacek, and former master’s student, Maggie Dransfeld, on their recent publication:

Disruption of metabolic, sleep, and sensorimotor functional outcomes in a female transgenic mouse model of Alzheimer’s disease. Behav Brain Res. 2020 Nov 1;398:112983. 


New Publication in Journal of Stroke and Cerebrovascular Diseases

Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke

Nada El Husseini, Cheryl Bushnell, Candice M. Brown, Deborah Attix, Natalia S. Rost, Gregory P. Samsa, Carol A. Colton, Larry B. Goldstein


This publication is part of an ongoing collaboration with Cheryl Bushnell, MD at Wake Forest Baptist Medical Center. It is a follow-up to a previous publication in Translational Stroke Research.