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Recent Articles
  • A. L. Brichacek, S.A. Benkovic, S. Chakraborty, D.C. Nwafor, W. Wang, S. Jun, W.J. Geldenhuys, A.B. Pinkerton, J.L. Millán, C.M. Brown. Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis. Sci Rep 9, 18788 (2019) DOI:10.1038/s41598-019-55154-2
  • D.C. Nwafor, S. Chakraborty, A.L. Brichacek, Sujung Jun, C.A. Gambill, Wei Wang, E.B. Engler-Chiurazzi, D. Dakhlallah, A.S. Pinkerton, J.L. Millan, S.A. Benkovic, and C.M. Brown. Loss of tissue non-specific alkaline phosphatase activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis. Brain Behavior Immunity. DOI: 10.1016/j.bbi.2019.11.016
  • D. Quintana, S.E. Lewis, Y. Anantula, J.A. Garcia, S.N. Sarkar, J.Z. Cavendish, C.M. Brown, J.W. Simpkins. (2019) The cerebral angiome: high resolution microCT imaging of the whole brain cerebrovasculature in female and male mice. Neuroimage. 202: 116109.  DOI: 10.1016/j.neuroimage.2019.116109
  • D.A. Dakhlallah, J. Wisler, M. Gencheva, C.M. Brown, E.R. Leatherman, K. Singh, K. Brundage, T. Karsies, A. Dakhlallah, K.W. Witwer, C.K. Sen, T.D. Eubank, and C.B. Marsh. (2019) Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock. J Extracell Vesicles. 8 (1):1669881. DOI: 10.1080/20013078.2019.1669881
  • D.C. Nwafor, A.L. Brichacek, S. Chakraborty, C.A. Gambill, S.A. Benkovic, C.M. Brown. (Forthcoming). Neuroendocrine and Neuroimmune Mechanisms Regulating the Blood-Brain Barrier. In Oxford Encyclopedia of Neuroendocrine and Autonomic Systems, ed. Randy J. Nelson. New York and Oxford: Oxford University Press. DOI:10.1093/acrefore/9780190264086.013.ORE_NEU-00307.R1
  • D.C. Nwafor, A.L. Brichacek, J.I. Griffith, A.S. Mohammed, B.P. Lucke-Wold, S. A. Benkovic, W.J. Geldenhuys, P. R. Lockman, C.M. Brown. Targeting the blood-brain barrier to prevent sepsis-associated cognitive impairment. Journal of Central Nervous System Disorders  DOI: http://10.1177/1179573519840652
  • A. L. Brichacek and C.M. Brown. Alkaline phosphatase: a biomarker for stroke and implications for treatment. Metab Brain Dis. 2018 Oct 4. DOI: http://10.1007/s11011-018-0322-3
Recent Abstracts
Rust Belt Microbiome Conference
  • A.L. Brichacek, D.C. Nwafor, M.E. Mace, C.M. Brown. Deletion of endothelial tissue-nonspecific alkaline phosphatase enhances gut dysbiosis in murine experimental sepsis. Rust Belt Microbiome Conference, November 2019, Pittsburgh, PA USA
  • M. E. Mace, A.L. Brichacek, S.M. Kenney, R.V. Macom, C.M. Brown. Overexpression of endothelial tissue-nonspecific alkaline phosphatase decreases gut dysbiosis in experimental sepsis. Rust Belt Microbiome Conference, November 2019, Pittsburgh, PA USA
  • S. M. Kenney, A.L. Brichacek, D.C. Nwafor, C.M. Brown. Dysbiosis of the gut microbiome following experimental sepsis in Alzheimer’s disease transgenic mice. Rust Belt Microbiome Conference, November 2019, Pittsburgh, PA USA
Alzheimer’s Association International Conference
  • D.C. Nwafor, A.L Brichacek, S. Gupta, C.A. Gambill, S.A. Benkovic, C.M. Brown. Polymicrobial infection exacerbates neuroinflammation and worsens Alzheimer’s associated memory loss in a female Alzheimer’s disease transgenic mice model. Oral presentation at the Alzheimer’s Association International Conference, July 2019, Los Angeles, CA USA DOI: https://doi.org/10.1016/j.jalz.2019.06.4474
  • D. Dakhlallah and C.M. Brown. Sepsis extracellular vesicles as epigenetic mediators of systemic communication in murine Alzheimer model. Poster presentation at the Alzheimer’s Association International Conference, July 2019, Los Angeles, CA USA. DOI: https://doi.org/10.1016/j.jalz.2019.06.3289

International Stroke Conference

  • A.L. Brichacek, C.A. Gambill, S. Kenney, D.C. Nwafor, H. Hu, X. Ren, S.A. Benkovic, C.M. Brown. Experimental Stroke Induces Chronic Gut Dysbiosis in Male C57BL/6J Mice. Moderated poster for the International Stroke Conference, February 2019, Honolulu, HI USA DOI: https://doi.org/10.1161/str.50.suppl_1.TP117
Gordon Conference: Neuroimmune Communication in Health and Disease
  • A. L. Brichacek, C.A. Gambill, S.M. Kenney, Y. Tze, S.A. Benkovic, A. Infante, D. Gemoets, D. Primerano, J. Franko, R. Schafer, C.M. Brown. (2019) Age and sex are determinants of the gut-brain-microbiota axis in a mouse model of Alzheimer’s disease. Poster presentation at the Neuroimmune Communication in Health and Disease Gordon Research Seminar and Gordon Research Conference, January 2019, Ventura Beach Marriott, Ventura, CA, USA
  • D.C. Nwafor, C.A. Gambill, A.L. Brichacek, S. Chakraborty, S.A. Benkovic, C.M. Brown. (2019). Progression of Alzheimer’s Disease Associated Memory Loss is Exacerbated in Septic Female Alzheimer’s Disease Transgenic Mice. Poster presentation at the Neuroimmune Communication in Health and Disease Gordon Research Seminar and Gordon Research Conference, January 2019, Ventura Beach Marriott, Ventura, CA, USA
  • C.A. Gambill, A.L. Brichacek, D.C. Nwafor, A. Infante, D. Gemoets, D. Primerano, J. Franko, R. Schafer, S.A. Benkovic, and C.M. Brown. The gut-brain-microbiota axis is altered in aged human nitric oxide synthase 2 (NOS2) transgenic mice compared to aged wild type mice in experimental sepsis. Gordon Conference: Neuroimmune Communication in Health and Disease January 2019 Ventura CA.