Please see recent posting in SfN Neurojobs and our Research page on TNAP and the blood-brain barrier.

The overall research project will focus on brain and gut endothelial cell dysfunction in ischemic stroke. These studies will contribute to our lab’s overall goal of understanding the anti-inflammatory mechanisms of tissue nonspecific alkaline phosphatase (TNAP) in the central and enteric nervous system. Two specific projects are available to study the role of alkaline phosphatases in ischemic stroke: 1) tissue nonspecific alkaline phosphatase (TNAP)-mediated regulation of blood-brain barrier function and 2) alkaline phosphatases as modifiers of the gut-brain-microbiota axis. Please contact Dr. Candice Brown (cdbrown2@hsc.wvu.edu) for more information.