The overall research project will focus on brain and gut endothelial cell dysfunction in ischemic stroke. These studies will contribute to our lab’s overall goal of understanding the anti-inflammatory mechanisms of tissue nonspecific alkaline phosphatase (TNAP) in the central and enteric nervous system. Two specific projects are available to study the role of alkaline phosphatases in ischemic stroke: 1) tissue nonspecific alkaline phosphatase (TNAP)-mediated regulation of blood-brain barrier function and 2) alkaline phosphatases as modifiers of the gut-brain-microbiota axis. Please contact Dr. Candice Brown (firstname.lastname@example.org) for more information.
Congratulations to Allison Brichacek on her first-author publication: Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.